The next frontier in vaccine design: blending immune correlates of protection into rational vaccine designReview Published on 2022-10-012022-10-05 Journal: Current opinion in immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] accelerate accelerated antibody Antibody binding canonical Community Complete death embedding immune correlate Immune profile Immunity immunological lack neutralization pathogen populations protective vaccines question raised severe disease the vaccine to define Vaccine Vaccine design Vaccine development Vaccines variants of concern Viral variants waned [DOI] 10.1016/j.coi.2022.102234 [Article Type] Review
Discovery of new drug indications for COVID-19: A drug repurposing approachCOVID-19에 대한 신약 적응증의 발견: 약물 용도 변경 접근Article Published on 2022-05-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] addition adopted Analysis anti-SARS-CoV-2 antiviral activity approach approved Baricitinib benefit binding energy calculated candidate drugs carried caused Cluster cluster analysis Clustering Combination Compound coronavirus demonstrated Dexamethasone docking result docking results docking study Doxorubicin drug drugs effective embedding Final generate generic drugs Health help in-silico In-vitro indication Interaction likelihood measure optics Ordering outbreak outlier performed Point PubChem public health Remdesivir Research Safety measures SARS-CoV-2 similarity stochastic Structure suggested Symptom Target genes therapy unique utility [DOI] 10.1371/journal.pone.0267095 PMC 바로가기 [Article Type] Article
ADA-COVID: Adversarial Deep Domain Adaptation-Based Diagnosis of COVID-19 from Lung CT Scans Using Triplet EmbeddingsResearch Article Published on 2022-02-082022-10-31 Journal: Computational Intelligence and Neuroscience [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Accuracy Affect Algorithms approach COVID-19 COVID-19 diagnosis dataset deep diagnose diagnosing diagnosis of COVID-19 domain early stages embedding evaluated F 1 score Generalizability generate implementation improvement infected cases inherent lung CT scan Precision Rapid recall receive reducing reliability Research similarity tested Triplet [DOI] 10.1155/2022/2564022 PMC 바로가기 [Article Type] Research Article
Embeddings from protein language models predict conservation and variant effectsArticle Published on 2021-12-302022-11-15 Journal: Human Genetics [Category] COVID19(2023년), SARS, 변종, [키워드] Algorithm alignment Amino acid analyses applied approach data set database deep deep learning Effect embedding entire sequence expand experiment fraction human proteins investigated language Local Logistic regression magnitude Model Multiple sequence alignment Nvidia Pearson correlation predict predicted prediction Probability Protein protein sequences Proteins proteome regions residue RTX SARS-CoV-2 variant scanning score sequence Sequence conservation significantly Spearman statistically supplementary material variant while [DOI] 10.1007/s00439-021-02411-y PMC 바로가기
Transcriptional Profiling and Machine Learning Unveil a Concordant Biosignature of Type I Interferon-Inducible Host Response Across Nasal Swab and Pulmonary Tissue for COVID-19 Diagnosis전사 프로파일링 및 기계 학습, COVID-19 진단을 위한 비강 면봉 및 폐 조직 전반에 걸쳐 I형 인터페론 유도성 숙주 반응의 일치하는 생체특징 공개Immunology Published on 2021-11-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] adjusted adopted Analysis approach approach biosignature BST2 caused complementary computational analysis concordant conserved COVID-19 COVID-19 diagnosis data interpretation dataset Diagnosis Diagnostic method embedding Factor false-negative Genes geometric global pandemic GSE147507 heterogeneous high mortality homological Host host response IFIT1 IFIT2 IFIT3 IFITM1 IFN-I IFN-I signaling infection control Interferome interferon involved ISG15 Limited lung tissue machine learning morbidity MX1 MX2 nasal swab NCBI-GEO network OAS1 OAS2 OAS3 OASL objective other respiratory infections outcome Profiling pulmonary respiratory respiratory infections response Result retrieved RNA-seq data RNA-sequencing RSAD2 RT-PCR SARS-CoV-2 SARS-CoV-2 virus sequencing data severity of COVID-19 similarity Stat1 stochastic stratified transcriptional transcriptional level transcriptomics Type type I interferon virus was used WGCNA [DOI] 10.3389/fimmu.2021.733171 PMC 바로가기 [Article Type] Immunology
Topics and Sentiments of Public Concerns Regarding COVID-19 Vaccines: Social Media Trend AnalysisCOVID-19 백신에 대한 대중적 우려의 주제와 감정: 소셜 미디어 동향 분석Original Paper Published on 2021-10-212022-09-10 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 치료기술, [키워드] Administered agency Analysis analyzed bidirectional build collected Combination communication concern COVID-19 COVID-19 vaccine COVID-19 vaccines Dictionary discussion duplicate embedding Emergency use authorization emotion emotional event fear followed by group Health health care informatics health information herd immunity Hesitancy highest identify Immunity Local media negative emotion negative emotions objective positive Positive emotion positive emotions Public Research Result selected sentiment similarity social media The United States the vaccine the vaccines Topic topic detection transformer trend Trust Twitter United States unsupervised sentiment analysis vaccination vaccination rate Vaccine Vaccine hesitancy Vaccines valence Volume were expressed [DOI] 10.2196/30765 PMC 바로가기 [Article Type] Original Paper
Staying ‘Covid‐safe’: Proposals for embedding behaviours that protect against Covid‐19 transmission in the UKOriginal Article Published on 2021-08-312022-10-28 Journal: British journal of health psychology [Category] COVID-19, MERS, SARS, [키워드] Behaviour change build Cabinet change COVID‐19 Culture develop education embedding Emergency Evidence group identify identity infection control information insight long‐term maintaining management objective office physical Policy PROTECT Regulation required resource Result risk SAGE SARS‐CoV‐2 sustaining Transmission United Kingdom were used [DOI] 10.1111/bjhp.12557 PMC 바로가기 [Article Type] Original Article
A qualitative exploration of medical students’ placement experiences with telehealth during COVID-19 and recommendations to prepare our future medical workforceResearch Published on 2021-08-162022-10-28 Journal: BMC Medical Education [Category] COVID-19, MERS, SARS, [키워드] analysed assist Australians clinical Clinical training clinician COVID-19 education embedding equity expressed expressing focus formative Future group healthcare hospital implementation IMPROVE increasingly Pandemics Patient care populations recommendation recommendations Research Result Rural health telehealth thematic analysis workforce [DOI] 10.1186/s12909-021-02719-3 PMC 바로가기 [Article Type] Research
Impact of vaccine supplies and delays on optimal control of the COVID-19 pandemic: mapping interventions for the PhilippinesResearch Article Published on 2021-08-092022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, MERS, [키워드] addressed administer administration assumption Asymptomatic changes in Combination Community compartmental model condition country COVID-19 COVID-19 pandemic effective embedding example faster identify immunization Impact implementation increase in increases in Infection infections Intervention introduced Isolation Local maintain measure Measures National Non-pharmaceutical interventions Optimal control pandemic Philippines platform reduce reduction Result resulting shifting Simulation supplementary material Surveillance symptomatic case symptomatic cases the vaccine Treatment vaccination Vaccinations Vaccine vaccine administration vaccine availability Vaccines [DOI] 10.1186/s40249-021-00886-5 PMC 바로가기 [Article Type] Research Article
Deep sequence modelling for predicting COVID-19 mRNA vaccine degradationBioinformatics Published on 2021-06-222022-10-29 Journal: PeerJ Computer Science [Category] COVID-19, [키워드] accelerate administration applied Bacteria base bidirectional candidate vaccine Celsius codon coronavirus COVID-19 COVID-19 vaccine dataset deaths deep Degradation determine disease-causing effort embedding feature Features FIVE Gated reccurent unit (GRU) high temperature immune system in vivo inefficient Infection less likelihood Long short time memory (LSTM) mRNA mRNA vaccine nucleotide organism outperform pandemic Pathogens predict predicted produced Protein protein expression rapid progress reactivity Reccurent neural networks (RNN) recognize responsible RNA RNA sample Safe secondary structure sequence several limitations Stanford treat Vaccine virus [DOI] 10.7717/peerj-cs.597 PMC 바로가기 [Article Type] Bioinformatics